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May 29, 2009


MTHFR-I Have It. Do You?

“Methylenetetrahydrofolate reductase (MTHFR) is a rare genetic defect that can lead to complications in pregnancy. Many people do not know that they have this defective gene until after they have had several unsuccessful pregnancies. Others may carry one pregnancy to term and not discover until afterwards that they carry the defect.”

You can call it MotherFucker.   We all do.  Even the nurses at the RE Factory!

Before we started this donor egg IVF cycle, I made sure they did an RPL (recurrent pregnancy loss) panel on me, even though I only had one m/c.  My acupuncturist seemed pretty certain 2 of my other cycles were early losses and I wanted to rule out everything possible to make sure this cycle had the best chance of success.

Now I know that I have one mutation of MTHRF (C677T).  That means I am heterozygous. It is reported that nearly half the population is MTHFR heterozygous.  This is the best case scenario when it comes to MTHFR.  This is rather easy to work with, thank goodness.

I wished I’d had this test done sooner, because I could’ve been taking something as simple as a baby aspirin a day + extra folic acid, vitamins B6 and B12 to achieve a successful pregnancy.  Had I only known.

Here’s where it gets tricky:  How much is enough?  My RE is content with the baby aspirin but I think I might need to add more to the mix (like Folgard?).

Here’s what I’m currently on:

  • Prenatal:800 mcg of folic acid, 15 mg of B6 and 25 mcg of B12
  • B12/Folic Acid/B6 tab with 2mg B6, 1000 mcg B12 and 800 mcg folic acid
  • In addition I add wheat germ to a smoothie every day with “20% folic acid”

I’ve read that you should have 2.2 mg Folic Acid, 25 mg B6 and 500 mcg B12.  So, bare with me on my math skills here, but it looks like I’ve pretty much got the B’s covered and it’s just the folic acid I could be lacking, is that right??

So confusing and complicated.  What I don’t understand if if a baby aspirin can’t hurt, why don’t they just have most TTC women on it??

Also, those of you out there who suffer from migraines (I’m thinking of you Carrie) this gene has also been linked to migraines.

If any of you have any advice for me…I’d love to hear it!